SOLU-PRED Injection 125mg

Description

Solu-Pred
(Methylprednisolone Sodium Succinate)
Sterile Powder 125mg, 500mg, 1g vial

RHEUMATOLOGY INDICATIONS

• Solu-Pred has indications for the management of acute rheumatic carditis, acute gout, ankylosing spondylitis, dermapomyositis and polymyositis, psoriatic arthritis and rheumatoid arthritis, including the juvenile type and systemic lupus erythematosus.
• Intraarticular and soft tissue administration in acute gouty arthritis, acute and subactue bursitis, acute tonosynovitis, epicondylitis, and synovitis of osteo arthritis.
• Intralesional administration in alopecia areata, discoid lupus erythemaposus, keloid disease, and lichen planus.

RHEUMATIC DISORDERS UNRESPONSIVE TO STANDARD THERAPY (OR DURING EXACERBATION EPISODES)

Administer either regimen as IV pulse dosing over at least 30 minutes. The regimen may be repeated if improvement has not occurred within a week after therapy or as the patient’s condition dictates. 1g/day for 1 to 4 days, or 1g/month for 6 months.

NEPHROLOGY INDICATIONS

Solu-Pred is helpful in the management of nephrotic syndrome, idiopathic type, or secondary to lupus nephritis.

SYSTEMIC LUPUS ERYTHEMATOSUS UNRESPONSIVE TO STANDARD THERAPY (OR DURING EXACERBATION EPISODES)

Administer 1g/day for 3 days as IV pulse dosing over at least 30 minutes. The regimen may be repeated if improvement has not occurred within a week after therapy, as the patient’s condition dictates.

EDEMATOUS STATES, SUCH AS GLOMERULONEPHRITIS OR LUPUS NEPHRITIS, UNRESPONSIVE TO STANDARD THERAPY (OR DURING EXACERBATION EPISODES)

Administer either regimen as IV pulse dosing over at least 30 minutes. The regimen may be repeated if improvement has not occurred within 1 week after therapy, or as the patient’s condition dictates. 30 mg/kg every other day for 4 days, or 1g/day 3,5 or 7 days.

NEUROLOGY INDICATIONS

In neurology, it is the mainstay therapy in acute exacerbations of multiple sclerosis.

MULTIPLE SCLEROSIS UNRESPONSIVE TO STANDARD THERAPY (OR DURING EXACERBATION EPISODES)

Administer 500mg/day or 1g/day for 3 or 5 days as IV pulse dosing over at least 30 minutes. The regimen may be repeated if improvement has not occurred within a week after therapy, as the patient’s condition dictates.

ACUTE SPINAL CORD INJURY

Treatment should begin within 8 hours of injury. For patients initiated on treatment within 3 hours of injury administer 30 mg/kg as an IV bolus over a 15-minute peroid, followed by a 45-minute pause, and then a continuous IV infusion of 5.4 mg/kg/h for 23 hours.
For patients initiated on treatment within 3 to 8 hours of injury:

Admininster 30 mg/kg as an IV bolus over a 15-minute period, followed by a 45-minute pause, and then a continuous IV infusion of 5.4 mg/kg/h for 47 hours.

There should be a separate intravenous site for the infusion pump.

IN OTHER INDICATIONS EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
Two dose regimens have been studied:
0.5 mg/kg IV every 6 hours for 72 hours, or 125 mg IV every 6 hours for 72 hours, switch to an oral corticosteroid and taper dose. Total treatment period sould be at least 2 weeks.

TERMINAL CANCER (TO IMPROVE QUALITY OF LIFE)

Administer 125 mg/day IV for up to 8 weeks. Adjunctive therapy in life threatening conditions. Administer 30 mg/kg IV over a period of at least 30 minutes. Dose may be repeated every 4 to 6 hours for up to 48 hours.

ADJUNCTIVE THERAPY IN LIFE THREATENING CONDITIONS

Administer 30 mg/kg IV over a period of at least 30 minutes. Dose may be repeated every 4 to 6 hours for up to 48 hours.

THE WIDELY USED POTENT GLUCOCORTICOID

• Ensures better anti-inflammatory potency than Hydrocortisone 04 to 05 times more potent than Hydrocortisone
• Offers faster onset of action than Dexamethasone • More potent & more selective than Prednisolone
  Effective for both: acute periods & long term management of autoimmune diseases like: SLE (Systemic Lupus Erythematosus)
• Potentiates action of bronchodilators with improvement in air flow parameters